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زیست شناسی::
گیرندهی لیپوپروتئین وابسته به پروتئین1
Low density lipoprotein receptorrelated protein 1 (LRP1) is a cell surface signaling protein that binds lipoproteins and other ligands and removes them from the bloodstream.
Following synthesis in the endoplasmic reticulum, LRP1 is escorted to the Golgi by a chaperone protein, receptorassociated protein (RAP).
(A) Following binding of exogenous RAP to lowdensity lipo protein receptorrelated protein 1 (LRP1) in the cell membrane, the protein complex is taken into the cell by endocytosis.
Acidsensitive wildtype RAP is denatured in the acidic endosome and releases LRP1, which is recycled back to the cell mem brane.
Exploiting its high affinity for LRP1, RAP can also be administered exogenously to inhibit binding of blood coagulation proteins to the recep tors and thereby prevent bleeding episodes in hemophiliacs.
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